Lipid-lowering agent-2
Lipid-lowering agent-2 (Compound 14d) is an orally active lipid-lowering agent with an EC50 of 0.06 μM. Lipid-lowering agent-2 inhibits the lipid synthesis, activates the AMPK signaling pathway, and exhibits anti-obesity effect. Lipid-lowering agent-2 inhibits food intake, improves the glucose metabolism, and reduces the body weight and adipose tissue in high-fat diet (HFD) -induced obese mice[1].
Product Specifications
UNSPSC
12352211
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lipid-lowering-agent-2.html
Smiles
O=C(N/N=C/C1=C(NC2=CC=CC=C21)C3=NC4=C(C(NCCN5CCCC5)=N3)C=CC=C4)C
Molecular Formula
C25H27N7O
Molecular Weight
441.53
References & Citations
[1]Jiang Z, et al., Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group. J Med Chem. 2024 Jul 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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