Anticancer agent 188
Anticancer agent 188 (compound D43) inhibits DNA synthesis in TNBC cells, leading to cell cycle arrest at the G2/M phase. Anticancer agent 188 has anti-cancer viability by inducing ROS-mediated apoptosis and DNA damage[1].
Product Specifications
CAS Number
[1207377-56-7]
UNSPSC
12352005
Target
DNA/RNA Synthesis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-188.html
Purity
99.10
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1C(C2=NC(C3=C(F)C=CC=C3)=N1)=NC(N(C)C2=O)=O
Molecular Formula
C13H10FN5O2
Molecular Weight
287.25
References & Citations
[1]Tingyue Wu, et al. Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducin. Sci Rep. 2024, 14, 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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