MY-11B

MY-11B is a DCAF1 ligand. MY-11B shows reactivity with DCAF1_C1113. MY-11B blockes YT41R and YT47R-mediated degradation of HA-FKBP12. MY-11B can be used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

2929223-25-4

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/my-11b.html

Smiles

O=C([C@@H]1N(C(C=C)=O)C[C@@H]1C2=CC=C(C#C)C=C2)NC3=C4N=CC=CC4=CC=C3

Molecular Formula

C24H19N3O2

Molecular Weight

381.43

References & Citations

[1]Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144 (40) :18688-18699.