MY-11B
MY-11B is a DCAF1 ligand. MY-11B shows reactivity with DCAF1_C1113. MY-11B blockes YT41R and YT47R-mediated degradation of HA-FKBP12. MY-11B can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
2929223-25-4
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/my-11b.html
Smiles
O=C([C@@H]1N(C(C=C)=O)C[C@@H]1C2=CC=C(C#C)C=C2)NC3=C4N=CC=CC4=CC=C3
Molecular Formula
C24H19N3O2
Molecular Weight
381.43
References & Citations
[1]Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144 (40) :18688-18699.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DCAF1
Frequently Asked Questions
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