XRD-0394
XRD-0394 is a potent and orally active dual ATM and DNA-PKcs inhibitor with IC50s of 0.39 nM and 0.89 nM, respectively. XRD-0394 shows selectivity over other PIKK and PI3K family members. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro[1].
Product Specifications
CAS Number
2595308-10-2
UNSPSC
12352005
Target
ATM/ATR; DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xrd-0394.html
Purity
98.54
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(C12CCC2)N(C)C3=C1C4=CC(C5=CN=C(OCCNC(C)C)C(NS(C)(=O)=O)=C5)=C(F)C=C4N=C3
Molecular Formula
C26H30FN5O4S
Molecular Weight
527.61
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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