Lanabecestat (hydrochloride)
Lanabecestat (AZD-3293) hydrochloride is a potent BACE1 inhibitor that has been investigated for its potential as a modifying treatment for Alzheimer's disease. Lanabecestat (hydrochloride) demonstrated significant dose- and time-dependent reductions in concentrations of amyloid beta peptides in plasma, cerebrospinal fluid, and brain. Lanabecestat (hydrochloride) was also shown to produce reductions in Aβ neuritic plaque burden without demonstrating clinical benefits or slowing the progression of Alzheimer's disease pathophysiology.
Product Specifications
CAS Number
[1383986-31-9]
Product Name Alternative
AZD-3293 (hydrochloride) ; LY3314814 (hydrochloride)
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lanabecestat-hydrochloride.html
Smiles
CC#CC1=CC(C2=CC([C@@]34N=C(C)C(N)=N4)=C(C[C@@]53CC[C@@H](OC)CC5)C=C2)=CN=C1.Cl
Molecular Formula
C26H29ClN4O
Molecular Weight
448.99
References & Citations
[1]Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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