PROTAC METTL3-14 degrader 1
PROTAC METTL3-14 degrader 1 (compound 30) is a PROTAC degrader of METTL3-14. PROTAC METTL3-14 degrader 1 shows a 50% or higher degradation of METTL3 and/or METTL14 (Pink: Ligand for target protein ; Black: Linker (HY-168686) ; Blue: Ligand for E3 ligase (HY-10984) ).
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-mettl3-14-degrader-1.html
Solubility
10 mM in DMSO
Smiles
CC1(C)CCN(CC2=C(F)C=C(N3CC4(CCN(C5=CC(NCCN6CCN(C(CCCCCNC7=C(C(N(C8CCC(NC8=O)=O)C9=O)=O)C9=CC=C7)=O)CC6)=NC=N5)CC4)NC(C3)=O)C(F)=C2)CC1
Molecular Formula
C51H66F2N12O6
Molecular Weight
981.14
References & Citations
[1]Francesco Errani, et al. Proteolysis Targeting Chimera Degraders of the METTL3–14 m6A-RNA Methyltransferase. JACS Au 2024, 4, 2, 713–729
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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