CVT-2759
CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation[1].
Product Specifications
CAS Number
342419-09-4
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cvt-2759.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N[C@H]4COCC4)O[C@@H]1COC(NC)=O
Molecular Formula
C16H22N6O6
Molecular Weight
394.38
References & Citations
[1]L Wu, et al. A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts. Am J Physiol Heart Circ Physiol. 2001 Jan;280 (1) :H334-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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