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(Rac) -Lanicemine

(Rac) -Lanicemine ((Rac) -AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively) . Antidepressant effects[1].

Product Specifications

CAS Number

[61890-25-3]

Product Name Alternative

(Rac) -AZD6765

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-lanicemine.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(C1=CC=CC=C1)CC2=NC=CC=C2

Molecular Formula

C13H14N2

Molecular Weight

198.27

Precautions

H315, H318, H335

References & Citations

[1]Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19 (9) :978-85.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Available Sizes

Curated Selection

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