VSW1198

VSW1198 is an inhibitor for geranylgeranyl diphosphate synthase (GGDPS) with an IC50 of 45 nM. VSW1198 reveals antitumor activity in myeloma- and prostate cancer with liver toxicity[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vsw1198.html

Solubility

10 mM in DMSO

Smiles

O=P(O[Na])(O[Na])C(P(O[Na])(O[Na])=O)CC1=CN(CC/C=C(C)/CC/C=C(C)/C)N=N1

Molecular Formula

C15H23N3Na4O6P2

Molecular Weight

495.27

References & Citations

[1]Haney SL, Varney ML, Chhonker Y, Talmon G, Smith LM, Murry DJ, Holstein SA. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway. Pharmacol Res. 2021 May;167:105528.