Atherosperminine

Atherosperminine (Atherospermine) is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC50 of 29.56 μg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis[1].

Product Specifications

CAS Number

[5531-98-6]

Product Name Alternative

Atherospermine

UNSPSC

12352005

Hazard Statement

H301-H315-H317-H319

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/atherosperminine.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCC1=C2C=CC3=CC=CC=C3C2=C(OC)C(OC)=C1

Molecular Formula

C20H23NO2

Molecular Weight

309.40

Precautions

P261-P264-P270-P272-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501

References & Citations

[1]Ayu Afiqah Nasrullah, et al. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae) . Molecules. 2013 Jul; 18 (7) : 8009–8017.|[2]C H Lin, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma. Eur J Pharmacol. 1993 Jun 11;237 (1) :109-16.