Cbz-Gly-Pro-Ala-O-cinnamyl
Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting BACE-1 and AChE with the IC50 values of 0.02 μM and 1 μM, respectively. Cbz-Gly-Pro-Ala-O-cinnamyl shows neuroprotective effect and can be used for study of Alzheimer’s disease[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Beta-lactamase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cbz-gly-pro-ala-o-cinnamyl.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(N1[C@@H](CCC1)C(N[C@H](C(OC/C=C/C2=CC=CC=C2)=O)C)=O)=O)OCC3=CC=CC=C3
Molecular Formula
C27H31N3O6
Molecular Weight
493.55
References & Citations
[1]Kaur B, et al. Small Peptides Targeting BACE-1, AChE, and A-β Reversing Scopolamine-Induced Memory Impairment: A Multitarget Approach against Alzheimer's Disease. ACS Omega. 2024;9 (11) :12896-12913. Published 2024 Mar 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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