Apoptosis inducer 19

Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2) . Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP) . Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research[1].

Product Specifications

CAS Number

[3049296-75-2]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptosis-inducer-19.html

Purity

98.31

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=CC=C(/C=C/C(C2=CC=C(OCC(N3CCCC3)=O)C=C2)=O)C=C1

Molecular Formula

C22H23NO4

Molecular Weight

365.42

References & Citations

[1]Kumar P, et al. Design, synthesis, and biological evaluation of chalcone acetamide derivatives against triple negative breast cancer. Bioorg Med Chem Lett. 2024 Jul 15;107:129795.