IDH1 Inhibitor 2

IDH1 Inhibitor 2 (compound 13) is a potent wild-type IDH1 inhibitor that exerts its activity through covalent modification of His315 with an IC50 value of 110 nM. IDH1 Inhibitor 2 can dose-dependently reduce the intracellular reduced glutamine metabolic flux, thereby affecting cellular metabolic homeostasis. IDH1 Inhibitor 2 can be used to study the role of IDH1 in cellular metabolic regulation and cancer development[1][2].

Product Specifications

CAS Number

[2244895-42-7]

UNSPSC

12352005

Target

Isocitrate Dehydrogenase (IDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/idh1-inhibitor-2.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C[C@@]2(C3=CC=CC=C3)[C@](CCC4=C2N=C(NC5=CC=CC=C5)N=C4)([H])[C@H](C)C1=O

Molecular Formula

C26H22N4O

Molecular Weight

406.48

References & Citations

[1]Jakob CG, et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1) : Direct Covalent Modification of His315. J Med Chem. 2018 Aug 9;61 (15) :6647-6657.|[2]Wt-IDH1 inhibition using a covalent and brain-penetrant small molecular inhibitor for ferroptosis induction in high-grade glioma. World Intellectual Property Organization, WO2023092034 A1 2023-05-25.