AX-024 (hydrochloride)

AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

Product Specifications

CAS Number

[1704801-24-0]

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

IFNAR; Interleukin Related; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ax-024-hydrochloride.html

Purity

99.23

Solubility

DMSO : 33 mg/mL (ultrasonic; warming) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl

Molecular Formula

C21H23ClFNO2

Molecular Weight

375.86

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8 (370) :370ra184.