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Buformin-d9 (hydrochloride)

Buformin-d9 (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1].

Product Specifications

Product Name Alternative

1-Butylbiguanide-d9 (hydrochloride)

UNSPSC

12352211

Target

AMPK; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Metabolic Disease

Solubility

10 mM in DMSO

Smiles

N=C(N)NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=N.[H]Cl

Molecular Formula

C6H7D9ClN5

Molecular Weight

202.73

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Amanda B Parris, et al. Buformin Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res|[3]Jing Li, et al. Buformin Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19 (6) :507-517.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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