L-680833

L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases[1].

Product Specifications

CAS Number

[127063-08-5]

UNSPSC

12352005

Target

Beta-lactamase; Elastase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-680833.html

Smiles

O=C(O)CC1=CC=C(O[C@@H](C2(CC)CC)N(C(N[C@@H](C3=CC=C(C)C=C3)CCC)=O)C2=O)C=C1

Molecular Formula

C27H34N2O5

Molecular Weight

466.57

References & Citations

[1]J B Doherty, et al. Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. Proc Natl Acad Sci U S A. 1993 Sep 15;90 (18) :8727-31.