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CaMdr1p-IN-1

CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM[1].

Product Specifications

CAS Number

[1257542-38-3]

UNSPSC

12352005

Target

ATP-binding cassette (ABC) transporters; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/camdr1p-in-1.html

Smiles

O=C1C(C(NC2=CC=CC=C2)=C1/C=C3N(C4=C(C\3(C)C)C=CC=C4)C)=O

Molecular Formula

C22H20N2O2

Molecular Weight

344.41

References & Citations

[1]Keniya MV, et al., Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance. PLoS One. 2015 May 7;10 (5) :e0126350.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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