3,3'-Difluorobenzaldazine
3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].
Product Specifications
CAS Number
15332-10-2
Product Name Alternative
DFB
UNSPSC
12352005
Hazard Statement
H302, H318, H400
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-3-difluorobenzaldazine.html
Purity
99.44
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1
Molecular Formula
C14H10F2N2
Molecular Weight
244.24
Precautions
H302, H318, H400
References & Citations
[1]O'Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64 (3) :731-740.|[2]Chan MH, et al. Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology (Berl) . 2008 May;198 (1) :141-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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