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3,3'-Difluorobenzaldazine

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].

Product Specifications

CAS Number

15332-10-2

Product Name Alternative

DFB

UNSPSC

12352005

Hazard Statement

H302, H318, H400

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-3-difluorobenzaldazine.html

Purity

99.44

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1

Molecular Formula

C14H10F2N2

Molecular Weight

244.24

Precautions

H302, H318, H400

References & Citations

[1]O'Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64 (3) :731-740.|[2]Chan MH, et al. Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology (Berl) . 2008 May;198 (1) :141-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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