Isovaleramide

Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1][2][3][4].

Product Specifications

CAS Number

[541-46-8]

Product Name Alternative

3-Methylbutanamide

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Isovaleramide.html

Purity

98.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C)CC(N)=O

Molecular Formula

C5H11NO

Molecular Weight

101.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Giraldo SE, et al. Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30 (2) :245-50.|[2]Yang K, et al. Isovaleramide attenuates ethylene glycol poisoning‐induced acute kidney injury and reduces mortality by inhibiting alcohol dehydrogenase activity in rats[J]. Basic & Clinical Pharmacology & Toxicology, 2024.|[3]Park H J, et al. Studies on the components of valerian and isovaleramide[J]. YAKHAK HOEJI, 2010, 54 (1) : 1-7.|[4]Manavi M A. Exploring Valeriana species: Unraveling anticonvulsant potential through phytochemistry and pharmacology. Future Natural Products, 2024, 9 (2) : 100-110.