CHET3
CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain[1].
Product Specifications
CAS Number
2489231-47-0
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chet3.html
Smiles
CC(C=C1)=CC=C1SCC(NC(NC(NC2=CC=C(OCCO3)C3=C2)=N)=N4)=CC4=O
Molecular Formula
C21H21N5O3S
Molecular Weight
423.49
References & Citations
[1]Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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