PI3K-IN-55
PI3K-IN-55 (Compound 6a) is a potent inhibitor for PI3K. PI3K-IN-55 affects PI3K/Akt/p53 signaling pathway, inhibits the proliferation of cancer cells A549, Hela, HepG2, MCF-7 and HT-29, with IC50s of 1.03-6.78 μM. PI3K-IN-55 induces apoptosis in cell MCF-7[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-55.html
Smiles
O=C(/C(C(/C=C/C1=CC=C(OCCO[N+]([O-])=O)C(OC)=C1)=O)=C/C2=CC=CS2)/C=C/C3=CC(OC)=C(OCCO[N+]([O-])=O)C=C3
Molecular Formula
C30H28N2O12S
Molecular Weight
640.61
References & Citations
[1]Zhou H, et al., In vitro anticancer study of novel curcumin derivatives via targeting PI3K/Akt/p53 signaling pathway. Mol Divers. 2024 Jul 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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