YT 6-2

YT 6-2 is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa[1].

Product Specifications

CAS Number

[2409959-90-4]

UNSPSC

12352005

Target

AUTACs

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yt-6-2.html

Smiles

FC(C=C1)=CC=C1COC2=C(C=CC(OC[C@H](O)CNCCO)=C2)OCC3=CC=C(C=C3)F

Molecular Formula

C25H27F2NO5

Molecular Weight

459.48

References & Citations

[1]NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, ALLEVIATING, OR TREATING PROTEIN ABNORMALITY DISORDERS. WO2020022783.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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