G9a-IN-2
G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC50 of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD) [1].
Product Specifications
CAS Number
2648853-26-1
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/g9a-in-2.html
Smiles
CN(CC1)CCC1OC2=CC=C(NC([C@@H](NC(C3=C(C)C(C(CC(C)(C)C4)=O)=C4N3)=O)CCCC)=O)C=C2
Molecular Formula
C30H42N4O4
Molecular Weight
522.68
References & Citations
[1]Nishigaya Y, et al., Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorg Med Chem Lett. 2024 Jun 22;110:129856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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