8-Hydroxyguanine

8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].

Product Specifications

CAS Number

[5614-64-2]

Product Name Alternative

8-Oxoguanine; 8-oxo-Gua

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/8-Hydroxyguanine.html

Purity

98.0

Solubility

1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 12 with 1M NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4.72 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)

Smiles

O=C1NC(N)=NC2=C1NC(N2)=O

Molecular Formula

C5H5N5O2

Molecular Weight

167.13

Precautions

H315, H319, H335

References & Citations

[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374 (2) :233-6.|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel) . 2023 Jun 19;12 (6) :1300.