8-Hydroxyguanine
Product Specifications
Product Name Alternative
2'3'-didehydro-2'3'-dideoxyadenosine
UNSPSC Description
8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.
Target Antigen
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-Hydroxyguanine.html
Purity
98.37
Solubility
1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 12 with 1M NaOH)|DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : < 1 mg/mL|H2O : 4.72 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)
Smiles
O=C1NC(N)=NC2=C1NC(N2)=O
Molecular Weight
167.13
References & Citations
[1]Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10.|[2]Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50.|[3]Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113338/8-Hydroxyguanine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113338/8-Hydroxyguanine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
5614-64-2
Available Sizes
Curated Selection
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