Fluoro-Dapagliflozin
Fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with Ki values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents[1].
Product Specifications
CAS Number
[1181681-43-5]
UNSPSC
12352005
Hazard Statement
H302
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fluoro-dapagliflozin.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)OCC)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)F)CO
Molecular Formula
C21H24ClFO5
Molecular Weight
410.86
Precautions
P264-P270-P330-P501
References & Citations
[1]Charles S Hummel, et al. Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15;302 (2) :C373-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT1; SGLT2
Available Sizes
Explore Other Products
Browse additional items from our catalog
Human MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, Beta) ELISA Kit
Human MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, Beta) ELISA Kit
