Fluoro-Dapagliflozin
Fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with Ki values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents[1].
Product Specifications
CAS Number
[1181681-43-5]
UNSPSC
12352005
Hazard Statement
H302
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fluoro-dapagliflozin.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)OCC)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)F)CO
Molecular Formula
C21H24ClFO5
Molecular Weight
410.86
Precautions
P264-P270-P330-P501
References & Citations
[1]Charles S Hummel, et al. Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15;302 (2) :C373-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT1; SGLT2
Available Sizes
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