LTB
LTB is a prodrug formed by coupling glycolysis inhibitor (Lonidamine (HY-B0486) ) with PD1/PDL1 blocker (BMS-1 (HY-19991) ) by thioketal linkage. LTB can further encapsulate photosensitizer chlorine e6 (Ce6) (HY-13594) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) by self-assembly[1].
Product Specifications
Product Name Alternative
Lon-TK-BMS-1
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ltb.html
Smiles
COC1=CC(OCC2=C(C(C3=CC=CC=C3)=CC=C2)C)=CC(OC)=C1CN4CCCC[C@H]4C(OCCCSC(C)(SCCCOC(C5=NN(C6=C5C=CC=C6)CC7=CC=C(C=C7Cl)Cl)=O)C)=O
Molecular Formula
C53H59Cl2N3O7S2
Molecular Weight
985.09
References & Citations
[1]Zhang Y, et al. Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient Immunosuppression reversion. Bioorg Chem. 2024 Dec;153:107978.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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