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Conantokin-T

Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa[1].

Product Specifications

CAS Number

[127476-26-0]

UNSPSC

12352209

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/conantokin-t.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)CC(C(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O

Molecular Formula

C110H175N31O45S

Molecular Weight

2683.81

References & Citations

[1]J A Haack, et al. Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity. J Biol Chem. 1990 Apr 15;265 (11) :6025-9.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P1287/Conantokin-T-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P1287/

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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