7-Hydroxy-2,2-dimethyl-4-chromanone

7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells[2].

Product Specifications

CAS Number

[17771-33-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-type Lectin-like Receptors (CTLRs)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-hydroxy-2-2-dimethyl-4-chromanone.html

Purity

97.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CC(C)(C)OC2=C1C=CC(O)=C2

Molecular Formula

C11H12O3

Molecular Weight

192.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561.|[2]Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11 (3) :321-7.