NY-ESO-1 (87-111)

NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide sequence. NY-ESO-1 (87-111) binds to multiple HLA-DR and HLA-DP4 molecules, and stimulates Th1-type and Th-2/Th0-type CD4+ T cells when presented in the context of HLA-DR and HLA-DP4 molecules[1].

Product Specifications

CAS Number

[508230-31-7]

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ny-eso-1-87-111.html

Solubility

H2O

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](N)CC(C)C)=O)=O)=O)CC2=CC=CC=C2)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCSC)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N4[C@@H](CCC4)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O

Molecular Formula

C131H206N32O36S2

Molecular Weight

2869.40

References & Citations

[1]Maja Mandic, et al. One NY-ESO-1-derived epitope that promiscuously binds to multiple HLA-DR and HLA-DP4 molecules and stimulates autologous CD4+ T cells from patients with NY-ESO-1-expressing melanoma. J Immunol. 2005 Feb 1;174 (3) :1751-9.