Robalzotan

Robalzotan (NAD-299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].

Product Specifications

CAS Number

[169758-66-1]

Product Name Alternative

NAD-299

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/robalzotan.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C[C@@H](N(C3CCC3)C4CCC4)COC2=C(F)C=C1)N

Molecular Formula

C18H23FN2O2

Molecular Weight

318.39

References & Citations

[1]Arborelius L, et al. The 5-HT (1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur J Pharmacol. 1999 Oct 8;382 (2) :133-8.|[2]Farde L, et al. PET-Determination of robalzotan (NAD-299) induced 5-HT (1A) receptor occupancy in the monkey brain. Neuropsychopharmacology. 2000 Apr;22 (4) :422-9. |[3]Hu, Xiao Jing, et al. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat. 2007.