Robalzotan
Robalzotan (NAD-299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].
Product Specifications
CAS Number
169758-66-1
Product Name Alternative
NAD-299
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/robalzotan.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C[C@@H](N(C3CCC3)C4CCC4)COC2=C(F)C=C1)N
Molecular Formula
C18H23FN2O2
Molecular Weight
318.39
References & Citations
[1]Arborelius L, et al. The 5-HT (1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur J Pharmacol. 1999 Oct 8;382 (2) :133-8.|[2]Farde L, et al. PET-Determination of robalzotan (NAD-299) induced 5-HT (1A) receptor occupancy in the monkey brain. Neuropsychopharmacology. 2000 Apr;22 (4) :422-9. |[3]Hu, Xiao Jing, et al. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat. 2007.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor; mLAG-3
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