OATD-01

OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1, IC50=23 nM) . OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research[1].

Product Specifications

CAS Number

[2088453-21-6]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oatd-01.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NNC(N2CCC(N3C[C@H](C)OC[C@@H]3CC4=CC=C(Cl)C=C4)CC2)=N1

Molecular Formula

C19H27ClN6O

Molecular Weight

390.91

References & Citations

[1]Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63 (24) :15527-15540.