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SmMLCK peptide

SmMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK) . The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction[1].

Product Specifications

CAS Number

172960-20-2

Product Name Alternative

Smooth-Muscle Myosin Light-Chain Kinase (796-815)

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/smmlck-peptide.html

Solubility

10 mM in DMSO

Smiles

C([C@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)[C@H](CC)C)=O)C)=O)CCCNC(=N)N)=O)C(C)C)=O)C)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3

Molecular Formula

C98H168N38O25

Molecular Weight

2278.62

References & Citations

[1]Hoffman L, et al.Relative Cosolute Size Influences the Kinetics of Protein-Protein Interactions. Biophys J. 2015 Aug 4;109 (3) :510-20.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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