SMK-17
SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations[1].
Product Specifications
CAS Number
765958-29-0
UNSPSC
12352005
Target
Apoptosis; MEK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smk-17.html
Smiles
O=S(NC1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)(N3CCC(CC3)NC(C)C)=O
Molecular Formula
C20H24ClF2IN4O2S
Molecular Weight
584.85
References & Citations
[1]Masaki Kiga, et al. SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors. Sci Rep. 2015 Feb 2:5:8155.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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