HCAIX-IN-21
HCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with KI values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-21.html
Smiles
O=C(C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=C(C)N(C4=CC=C(F)C=C4)N=N3)=C1)OC
Molecular Formula
C20H17FN6O4S
Molecular Weight
456.45
References & Citations
[1]Siwach K, et al. Benzenesulfonamides functionalized with triazolyl-linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action. Arch Pharm (Weinheim) . 2024 Jun 20:e2400114.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII
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