RS-25344 (hydrochloride)
Product Specifications
UNSPSC Description
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-25344-hydrochloride.html
Purity
99.93
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C1N(C2=CC=CC([N+]([O-])=O)=C2)C3=NC=CC=C3C(N1CC4=CC=NC=C4)=O
Molecular Weight
411.80
References & Citations
[1]Will McDonough, et al. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. FASEB J. 2020 Sep;34(9):12533-12548.|[2]J D Fisch, et al. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod. 1998 May;13(5):1248-54.|[3]T Kaneko, et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal. 1995 Jul;7(5):527-34.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108621/RS-25344-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108621/RS-25344-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
152815-28-6
Available Sizes
Curated Selection
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