Kresoxim-methyl

Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex) . Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme[1][2].

Product Specifications

CAS Number

[143390-89-0]

Product Name Alternative

BAS 490 F

UNSPSC

12352005

Hazard Statement

H351, H410

Target

Fungal; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kresoxim-methyl.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)/C(C1=CC=CC=C1COC2=CC=CC=C2C)=N/OC

Molecular Formula

C18H19NO4

Molecular Weight

313.35

Precautions

H351, H410

References & Citations

[1]Roehl F. Binding of BAS 490 F to bc1-complex from yeast. Biochem Soc Trans. 1994;22 (1) :64S.|[2]Köhle H, et al. Biokinetic properties of BAS 490 F and some related compounds. Biochem Soc Trans. 1994;22 (1) :65S.|[3]Flampouri E, et al. Strobilurin fungicide kresoxim-methyl effects on a cancerous neural cell line: oxidant/antioxidant responses and in vitro migration. Toxicol Mech Methods. 2018;28 (9) :709-716.