TPI-1
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
Product Specifications
CAS Number
[79756-69-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase; SHP1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/TPI-1.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CC(C2=CC(C=CC2=O)=O)=C(Cl)C=C1
Molecular Formula
C12H6Cl2O2
Molecular Weight
253.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184 (11) :6529-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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