AB182

AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.

Product Specifications

CAS Number

54805-58-2

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Assay Protocol

https://www.medchemexpress.com/ab182.html

Smiles

O=C(NOP(N1C(C)(C1)C)(N2C(C)(C2)C)=O)OCC

Molecular Formula

C11H22N3O4P

Molecular Weight

291.28

References & Citations

[1]Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979;5 (9) :1653-1656. |[2]Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5 (9) :1677-1680.