Tiamenidine (hydrochloride)
Tiamenidine hydrochloride (HOE 440 hydrochloride) is a centrally acting α1-adrenergic receptor antagonist with hypotensive activity. Tiamenidine hydrochloride regulates blood pressure levels by binding to α1 receptors. Tiamenidine hydrochloride can be used in the study of hypertension[1].
Product Specifications
CAS Number
51274-83-0
Product Name Alternative
HOE 440 (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tiamenidine-hydrochloride.html
Smiles
ClC1=C(NC2=NCCN2)C(C)=CS1.Cl
Molecular Formula
C8H11Cl2N3S
Molecular Weight
252.16
References & Citations
[1]D M Roden, et al. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther. 1988 Jun;43 (6) :648-54.|[2]D M Roden, et al. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther. 1988 Jun;43 (6) :648-54.|[3]Quantitative determination of tiamenidine hydrochloride in human serum using gas chromatography mass spectrometry
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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