DB-0646
DB-0646, a PROTAC, is a multi-kinase degrader[1].
Product Specifications
CAS Number
2769753-59-3
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db-0646.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=C(OCCCCCN4N=NC(CN5CCN(C6=NC=C(NC7=NC=C8C(N(C)C(N(C9=CC(NC(C%10=CC=CC(C(F)(F)F)=C%10)=O)=CC=C9C)C8)=O)=N7)C=C6)CC5)=C4)C=CC=C3C1=O
Molecular Formula
C52H51F3N14O7
Molecular Weight
1041.05
References & Citations
[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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