JBC117
JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis[1].
Product Specifications
CAS Number
[1214531-21-1]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jbc117.html
Purity
99.71
Solubility
10 mM in DMSO
Smiles
OC(CN1CCC2(CC1)OC3=C(C(C2)O)C=CC4=C3C=CC=C4)C5=CNC6=C5C=CC(C)=C6
Molecular Formula
C28H30N2O3
Molecular Weight
442.55
References & Citations
[1]Ali F, et al. Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2. Cancer Sci. 2016 Sep;107 (9) :1321-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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