U-0521
U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT) . U-0521 has the potential for the research of Parkinson's disease[1].
Product Specifications
CAS Number
[5466-89-7]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
COMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/u-0521.html
Purity
98.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C(C1=CC=C(C(O)=C1)O)=O)C
Molecular Formula
C10H12O3
Molecular Weight
180.20
Precautions
H302, H312, H332
References & Citations
[1]Reches A, et al. Effect of 3',4'-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31 (21) :3415-3418.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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