PROTAC EGFR degrader 11
Product Specifications
UNSPSC Description
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
Target Antigen
EGFR; FAK; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-egfr-degrader-11.html
Smiles
O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
Molecular Weight
991.61
References & Citations
[1]Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161633/PROTAC-EGFR-degrader-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161633/PROTAC-EGFR-degrader-11-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3034244-71-5
Available Sizes
Curated Selection
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