LY53857
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT2 receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves[1].
Product Specifications
CAS Number
60634-51-7
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ly53857.html
Smiles
OC(/C=C\C(O)=O)=O.CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(OC(C)C(O)C)=O)C)([H])CC3=C1)=CC=C2)C
Molecular Formula
C27H36N2O7
Molecular Weight
500.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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