Casimersen
Product Specifications
CAS Number
1422958-19-7
Product Name Alternative
SRP-4045
UNSPSC Description
Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD)[1].
Target Antigen
Others
Type
Oligonucleotides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/casimersen.html
Purity
91.57
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Casimersen]
Molecular Weight
7584.00
References & Citations
[1]Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879. |[2]Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150. |[3]Carver MP, Charleston JS, Shanks C, et al. Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates. J Neuromuscul Dis. 2016;3(3):381-393.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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