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Casimersen

Product Specifications

CAS Number

1422958-19-7

Product Name Alternative

SRP-4045

UNSPSC Description

Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD)[1].

Target Antigen

Others

Type

Oligonucleotides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/casimersen.html

Purity

91.57

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Casimersen]

Molecular Weight

7584.00

References & Citations

[1]Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879. |[2]Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150. |[3]Carver MP, Charleston JS, Shanks C, et al. Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates. J Neuromuscul Dis. 2016;3(3):381-393.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen, away from moisture)

Clinical Information

Launched

Available Sizes

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