Nauclefine
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1].
Product Specifications
CAS Number
[57103-51-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nauclefine.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C=C3C4=C(CCN13)C5=C(C=CC=C5)N4)C=CN=C2
Molecular Formula
C18H13N3O
Molecular Weight
287.32
Precautions
H315, H319, H320
References & Citations
[1]Youwei Ai, et al. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. Nat Commun. 2020 Jun 26;11 (1) :3236.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
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