Nauclefine

Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1].

Product Specifications

CAS Number

[57103-51-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Apoptosis; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nauclefine.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C=C3C4=C(CCN13)C5=C(C=CC=C5)N4)C=CN=C2

Molecular Formula

C18H13N3O

Molecular Weight

287.32

Precautions

H315, H319, H320

References & Citations

[1]Youwei Ai, et al. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. Nat Commun. 2020 Jun 26;11 (1) :3236.